Machine Learning Based Approaches for Cancer Classification Using Gene Expression Data

نویسندگان

  • Amit Bhola
  • Arvind Kumar Tiwari
چکیده

The classification of different types of tumor is of great importance in cancer diagnosis and drug discovery. Earlier studies on cancer classification have limited diagnostic ability. The recent development of DNA microarray technology has made monitoring of thousands of gene expression simultaneously. By using this abundance of gene expression data researchers are exploring the possibilities of cancer classification. There are number of methods proposed with good results, but lot of issues still need to be addressed. This paper present an overview of various cancer classification methods and evaluate these proposed methods based on their classification accuracy, computational time and ability to reveal gene information. We have also evaluated and introduced various proposed gene selection method. In this paper, several issues related to cancer classification have also been discussed.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Feature Selection and Classification of Microarray Gene Expression Data of Ovarian Carcinoma Patients using Weighted Voting Support Vector Machine

We can reach by DNA microarray gene expression to such wealth of information with thousands of variables (genes). Analysis of this information can show genetic reasons of disease and tumor differences. In this study we try to reduce high-dimensional data by statistical method to select valuable genes with high impact as biomarkers and then classify ovarian tumor based on gene expression data of...

متن کامل

Exploring Gene Signatures in Different Molecular Subtypes of Gastric Cancer (MSS/ TP53+, MSS/TP53-): A Network-based and Machine Learning Approach

Gastric cancer (GC) is one of the leading causes of cancer mortality, worldwide. Molecular understanding of GC’s different subtypes is still dismal and it is necessary to develop new subtype-specific diagnostic and therapeutic approaches. Therefore developing comprehensive research in this area is demanding to have a deeper insight into molecular processes, underlying these subtypes. In this st...

متن کامل

SFLA Based Gene Selection Approach for Improving Cancer Classification Accuracy

 In this paper, we propose a new gene selection algorithm based on Shuffled Frog Leaping Algorithm that is called SFLA-FS. The proposed algorithm is used for improving cancer classification accuracy. Most of the biological datasets such as cancer datasets have a large number of genes and few samples. However, most of these genes are not usable in some tasks for example in cancer classification....

متن کامل

Prediction of blood cancer using leukemia gene expression data and sparsity-based gene selection methods

Background: DNA microarray is a useful technology that simultaneously assesses the expression of thousands of genes. It can be utilized for the detection of cancer types and cancer biomarkers. This study aimed to predict blood cancer using leukemia gene expression data and a robust ℓ2,p-norm sparsity-based gene selection method. Materials and Methods: In this descriptive study, the microarray ...

متن کامل

Gene Identification from Microarray Data for Diagnosis of Acute Myeloid and Lymphoblastic Leukemia Using a Sparse Gene Selection Method

Background: Microarray experiments can simultaneously determine the expression of thousands of genes. Identification of potential genes from microarray data for diagnosis of cancer is important. This study aimed to identify genes for the diagnosis of acute myeloid and lymphoblastic leukemia using a sparse feature selection method. Materials and Methods: In this descriptive study, the expressio...

متن کامل

Classification and Biomarker Genes Selection for Cancer Gene Expression Data Using Random Forest

Background & objective: Microarray and next generation sequencing (NGS) data are the important sources to find helpful molecular patterns. Also, the great number of gene expression data increases the challenge of how to identify the biomarkers associated with cancer. The random forest (RF) is used to effectively analyze the problems of large-p and smal...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015